Today we have the pleasure to receive two intern students from Thailand. Thanatchaya and Varissara welcome to the Netherlands and to our lab! We hope you will have a good and productive time here learning about science but also about all the nice things our university and city, country, has to offer.

Today we heard that the manuscript describing the design of APC variants that can cleave histones in a better and more safe way was accepted in JTH. This was a long and tedious project, as reflected by the many authors who made a contribution, but finally Joram managed to get it published. Congrats to all!

Today on the 24th of June 2023 Johana has given birth to beautiful Emilie. Welcome to the world Emilie!

We wish Johana and Pavel lots of joy and luck with their daughter and toast on a long a happy life for her!

At the IDP Community F2F/hybrid meeting held on 3 and 4 July in Bratislava (SK) Kanin had a very succesfull presentation explaining how an intrinsically disordered protein like histones can be targeted. Response form the audience was very good and it means our lab is now a member of the IDP/Elixir community with Kanin as MC member.

After a very belated Christmas holiday that lasted for nearly 6 months to his homeland Turkey, Emre returned to his job

Welcome back Emre!

today Gwen has started her PhD. After first having worked with us as a Master student, rudely interrupted by the Corona pandemic, Gwen decided to return to our group and start a PhD on the topic of NETs, histones, PAD4 in health and disease.

Good luck for the coming years Gwen and enjiy the ride!

Friday the 13th is not necessarily bad as we found out today. Angelina’s manuscript on the discovery of new SMPD3 inhibitors was accepted today for publication. Congratulations!

This week was a very successfull one, with 2 papers accepted, one where Femke and Joram did a real good job in bringing together all data on the involvement of extracellular histones in COVID-19 and one where we investigated glycocalix degradation during coronary artery bypass grafting, together with our colleagues at the ICU.

After having experienced te Corona-pandemic and the inevitable consequences for organizing meetings, a next NSBM Meeting was held in collaboration with our Belgian friends from Brussels, as organized by Prof. Wim Vrancken of the VUB in Brussels, Belgium.

The meeting was titled:

Structural bioinformatics beyond AlphaFold2

location: U-residence aan de VUB (Pleinlaan 2, B-1050 Brussel)

There will be 3 sessions:  
1 – “Large scale AlphaFold2 analyses” – Christine Orengo, UCL, UK

2 – “Probabilistic approaches and representing conformational variability” – Max Bonomi, Institut Pasteur, Paris, France

3 – “Proteomics & protein structure” – Ron Heere, M4I, UM, NL

Today Emre started his position as post-doctoral fellow in our group. While he still needs to formally finalize his studies in Halle, he is now free to work on the topics of our research.
Welcome Emre and good luck!